eprintid: 35035
rev_number: 12
eprint_status: archive
userid: 77
dir: disk0/00/03/50/35
datestamp: 2019-05-20 06:31:33
lastmod: 2019-05-20 07:21:24
status_changed: 2019-05-20 06:31:33
type: thesis
metadata_visibility: show
creators_name: SHELLA AISIYAH DIVA, NIM. 14620012
title: PENGARUH KONSENTRASI KALSIUM DALAM SEL NEURON PADA PLASTISITAS SINAPSIS MODEL STDP (SPIKE TIMING DEPENDENT PLASTICITY)
ispublished: pub
subjects: F
divisions: jur_pefis
full_text_status: restricted
keywords: Calcium, LTP, LTD, synaptic plasticity, STDP.
note: Anis Yuniati, M.Si, Ph.D.
abstract: Synapses are the plastic cleft between neurons. The synaptic plasticity could perform long-term strengthening or Long Term Potentiation (LTP) and long-term weakening or Long Term Depression (LTD). LTP and LTD can be triggered by the changes of intracellular Calcium concentration. Spike-Timing Dependent Plasticity (STDP) is a synaptic modification that depends on the time spikes in presynapsis and postsynapsis. In this study we built a model that involving a mechanism of the effect of intracellular Calcium on the STDP phenomenon. This model used a mechanism involving parameters such as Calcium pumping, AMPA receptors, NMDA receptors, LTP enzyme and LTD enzyme. In this model, high Calcium concentrations will activate the LTP enzyme while low Calcium concentrations will activate the LTD enzyme, which trigger the occurrence of LTP and LTD respectively. The occurrence of LTP and LTD is the basis for the formation of the STDP curve. In this model, the parameters can be adjusted to obtain the STDP curve that realistic with the experimental results in which the LTP is observed in the range between 0 <Δt <50ms, while LTD is observed at wider intervals between 150ms <Δt <0. These parameters are related to decay time at NMDA receptors.
date: 2018-11-21
date_type: published
pages: 114
institution: UIN SUNAN KALIJAGA YOGYAKARTA
department: FAKULTAS SAINS DAN TEKNOLOGI
thesis_type: skripsi
thesis_name: other
citation:   SHELLA AISIYAH DIVA, NIM. 14620012  (2018) PENGARUH KONSENTRASI KALSIUM DALAM SEL NEURON PADA PLASTISITAS SINAPSIS MODEL STDP (SPIKE TIMING DEPENDENT PLASTICITY).  Skripsi thesis, UIN SUNAN KALIJAGA YOGYAKARTA.   
document_url: https://digilib.uin-suka.ac.id/id/eprint/35035/1/14620012_BAB%20I_BAB_TERAKHIR_DAFTAR_PUSTAKA.pdf
document_url: https://digilib.uin-suka.ac.id/id/eprint/35035/2/14620012_BAB%20II_S.D._SEBELUM_BAB_TERAKHIR.pdf