eprintid: 59631
rev_number: 11
eprint_status: archive
userid: 12460
dir: disk0/00/05/96/31
datestamp: 2023-07-06 06:24:53
lastmod: 2023-07-06 06:24:53
status_changed: 2023-07-06 06:24:53
type: thesis
metadata_visibility: show
contact_email: muh.khabib@uin-suka.ac.id
creators_name: Novita Sari Pranestri, NIM.: 18106040035
title: ANALISIS INTERAKSI SENYAWA MINYAK ATSIRI KAYU MANIS (Cinnamomum burmanii) DAN α-GLUKOSIDASE SECARA IN SILICO
ispublished: pub
subjects: BB
subjects: tan_tan
divisions: jur_bio
full_text_status: restricted
keywords: Diabates Melitus, Kayu Manis, Metode In Silico
note: Pembimbing: Anti Damayanti, H S.Si, M.Mol.Bio dan Dian Aruni Kumalawati, M.Sc
abstract: Type 2 diabetes melitus is a condition where patients experience a lack of insulin production which results in an increase in blood sugar levels beyond normal levels. One plant that is believed and used by the community as a cure for diabetes is the cinnamon plant (Cinnamomum burmannii). Bioactive compounds in cinnamon stem essential oil that have the ability to inhibit the work of α-glucosidase. The interaction of compounds that are α-glucosidase can be predicted by the in silico method. This study aims to screen and analyze compounds in cinnamon stem essential oil, namely Cinnamaldehyde, eugenol, coumarin, and cinnamyl acetate as ligands that have the potential to be inhibitors for α-glucosidase enzymes (receptors) in silico. The in silico method is used to predict the interaction and binding energy between bioactive compounds of cinnamon stem essential oil (ligands) with α-glucosidase proteins (receptors) that play a role in digestive metabolism. Essential oil compounds of cinnamon stems were analyzed by molecular docking. The docking results also show that the binding between the receptor and the ligand does not occur on the active side of the α-glucosidase, indicating that the ligand's inhibitory mechanism is as a competitive inhibitor. The results of the prediction of physicochemical properties of all compounds are categorized as good, the prediction of Lipinski's law for all compounds found no violations. ADME-Tox predictions for all four compounds are categorized as good so that they can qualify as good drug candidates. Based on these results, the couamrin compound in cinnamon stem essential oil can be proposed and further tested as a candidate for antidiabetic drugs.
date: 2023-04-25
date_type: published
pages: 82
institution: UIN SUNAN KALIJAGA YOGYAKARTA
department: FAKULTAS SAINS DAN TEKNOLOGI
thesis_type: skripsi
thesis_name: other
citation:   Novita Sari Pranestri, NIM.: 18106040035  (2023) ANALISIS INTERAKSI SENYAWA MINYAK ATSIRI KAYU MANIS (Cinnamomum burmanii) DAN α-GLUKOSIDASE SECARA IN SILICO.  Skripsi thesis, UIN SUNAN KALIJAGA YOGYAKARTA.   
document_url: https://digilib.uin-suka.ac.id/id/eprint/59631/1/18106040035_BAB-I_IV-atau-V_DAFTAR-PUSTAKA.pdf
document_url: https://digilib.uin-suka.ac.id/id/eprint/59631/2/18106040035_BAB-II_sampai_SEBELUM-BAB-TERAKHIR.pdf