@phdthesis{digilib71787,
           month = {June},
           title = {ANALISIS PROFIL ELUSI DAN KENDALI KUALITAS 99mTc HASIL PRODUKSI DARI GENERATOR 99Mo/99mTc NON-FISI BERBASIS CERIUM ALUMINA},
          school = {UIN SUNAN KALIJAGA YOGYAKARTA},
          author = {NIM.: 21106020034 Aidiana Mamluatun Ni?mah},
            year = {2025},
            note = {Siska Febriana, S.Si., M.Si dan Dr. Nita Handayani, S.Si., M.Si},
        keywords = {Profil Elusi, Kendali Kualitas. Cerium Alumina, 99Mo/99mTc generator non-fisi, Radioisotop},
             url = {https://digilib.uin-suka.ac.id/id/eprint/71787/},
        abstract = {Technetium-99m ({$^9$}{$^9$}?Tc) is the most widely used radioisotope in nuclear medicine diagnostics and is commonly produced from a {$^9$}{$^9$}Mo/{$^9$}{$^9$}?Tc generator. Due to the limitations of fission-based {$^9$}{$^9$}Mo production, alternative non-fission methods involving neutron activation of natural molybdenum (MoO{$_3$}) are being developed. This study aims to analyze the elution profile and quality control parameters of {$^9$}{$^9$}?Tc produced from a non-fission {$^9$}{$^9$}Mo/{$^9$}{$^9$}?Tc generator based on cerium-alumina material. Cerium was selected as the column filler material due to its high chemical stability. The elution of {$^9$}{$^9$}?Tc was carried out using a NaCl solution, and quality control included assessments of radionuclidic purity, pH, and alumina content. The results showed that the generator with a cerium-alumina column composition increased the {$^9$}{$^9$}?Tc yield by 6,62\% compared to a conventional alumina column. However, the {$^9$}{$^9$}Mo breakthrough still exceeded the limit set by the United States Pharmacopeia ({\ensuremath{>}}0,15 {\ensuremath{\mu}}Ci {$^9$}{$^9$}Mo/mCi {$^9$}{$^9$}?Tc). By adding an additional alumina column, the {$^9$}{$^9$}Mo breakthrough was reduced to 0,0015 {\ensuremath{\mu}}Ci {$^9$}{$^9$}Mo/mCi {$^9$}{$^9$}?Tc, thereby meeting clinical quality standards for {$^9$}{$^9$}?Tc. Overall, the findings demonstrate the potential of cerium-alumina-based non-fission generators for medical radioisotope production.}
}