TY  - THES
N1  - Siska Febriana, S.Si., M.Si dan Dr. Nita Handayani, S.Si., M.Si
ID  - digilib71787
UR  - https://digilib.uin-suka.ac.id/id/eprint/71787/
A1  - Aidiana Mamluatun Ni?mah, NIM.: 21106020034
Y1  - 2025/06/05/
N2  - Technetium-99m (???Tc) is the most widely used radioisotope in nuclear medicine diagnostics and is commonly produced from a ??Mo/???Tc generator. Due to the limitations of fission-based ??Mo production, alternative non-fission methods involving neutron activation of natural molybdenum (MoO?) are being developed. This study aims to analyze the elution profile and quality control parameters of ???Tc produced from a non-fission ??Mo/???Tc generator based on cerium-alumina material. Cerium was selected as the column filler material due to its high chemical stability. The elution of ???Tc was carried out using a NaCl solution, and quality control included assessments of radionuclidic purity, pH, and alumina content. The results showed that the generator with a cerium-alumina column composition increased the ???Tc yield by 6,62% compared to a conventional alumina column. However, the ??Mo breakthrough still exceeded the limit set by the United States Pharmacopeia (>0,15 ?Ci ??Mo/mCi ???Tc). By adding an additional alumina column, the ??Mo breakthrough was reduced to 0,0015 ?Ci ??Mo/mCi ???Tc, thereby meeting clinical quality standards for ???Tc. Overall, the findings demonstrate the potential of cerium-alumina-based non-fission generators for medical radioisotope production.
PB  - UIN SUNAN KALIJAGA YOGYAKARTA
KW  - Profil Elusi
KW  -  Kendali Kualitas. Cerium Alumina
KW  -  99Mo/99mTc generator non-fisi
KW  -  Radioisotop
M1  - skripsi
TI  - ANALISIS PROFIL ELUSI DAN KENDALI KUALITAS 99mTc HASIL PRODUKSI DARI GENERATOR 99Mo/99mTc NON-FISI BERBASIS CERIUM ALUMINA
AV  - restricted
EP  - 103
ER  -