%A NIM.: 21106020034 Aidiana Mamluatun Ni’mah
%O Siska Febriana, S.Si., M.Si dan Dr. Nita Handayani, S.Si., M.Si
%T ANALISIS PROFIL ELUSI DAN KENDALI KUALITAS 99mTc HASIL PRODUKSI DARI GENERATOR 99Mo/99mTc NON-FISI BERBASIS CERIUM ALUMINA
%X Technetium-99m (⁹⁹ᵐTc) is the most widely used radioisotope in nuclear medicine diagnostics and is commonly produced from a ⁹⁹Mo/⁹⁹ᵐTc generator. Due to the limitations of fission-based ⁹⁹Mo production, alternative non-fission methods involving neutron activation of natural molybdenum (MoO₃) are being developed. This study aims to analyze the elution profile and quality control parameters of ⁹⁹ᵐTc produced from a non-fission ⁹⁹Mo/⁹⁹ᵐTc generator based on cerium-alumina material. Cerium was selected as the column filler material due to its high chemical stability. The elution of ⁹⁹ᵐTc was carried out using a NaCl solution, and quality control included assessments of radionuclidic purity, pH, and alumina content. The results showed that the generator with a cerium-alumina column composition increased the ⁹⁹ᵐTc yield by 6,62% compared to a conventional alumina column. However, the ⁹⁹Mo breakthrough still exceeded the limit set by the United States Pharmacopeia (>0,15 μCi ⁹⁹Mo/mCi ⁹⁹ᵐTc). By adding an additional alumina column, the ⁹⁹Mo breakthrough was reduced to 0,0015 μCi ⁹⁹Mo/mCi ⁹⁹ᵐTc, thereby meeting clinical quality standards for ⁹⁹ᵐTc. Overall, the findings demonstrate the potential of cerium-alumina-based non-fission generators for medical radioisotope production.
%K Profil Elusi, Kendali Kualitas. Cerium Alumina, 99Mo/99mTc generator non-fisi, Radioisotop
%D 2025
%I UIN SUNAN KALIJAGA YOGYAKARTA
%L digilib71787