eprintid: 71787
rev_number: 10
eprint_status: archive
userid: 12460
dir: disk0/00/07/17/87
datestamp: 2025-07-11 09:10:10
lastmod: 2025-07-11 09:10:10
status_changed: 2025-07-11 09:10:10
type: thesis
metadata_visibility: show
contact_email: muh.khabib@uin-suka.ac.id
creators_name: Aidiana Mamluatun Ni’mah, NIM.: 21106020034
title: ANALISIS PROFIL ELUSI DAN KENDALI KUALITAS 99mTc HASIL PRODUKSI DARI GENERATOR 99Mo/99mTc NON-FISI BERBASIS CERIUM ALUMINA
ispublished: pub
subjects: 500
divisions: jur_fis
full_text_status: restricted
keywords: Profil Elusi, Kendali Kualitas. Cerium Alumina, 99Mo/99mTc generator non-fisi, Radioisotop
note: Siska Febriana, S.Si., M.Si dan Dr. Nita Handayani, S.Si., M.Si
abstract: Technetium-99m (⁹⁹ᵐTc) is the most widely used radioisotope in nuclear medicine diagnostics and is commonly produced from a ⁹⁹Mo/⁹⁹ᵐTc generator. Due to the limitations of fission-based ⁹⁹Mo production, alternative non-fission methods involving neutron activation of natural molybdenum (MoO₃) are being developed. This study aims to analyze the elution profile and quality control parameters of ⁹⁹ᵐTc produced from a non-fission ⁹⁹Mo/⁹⁹ᵐTc generator based on cerium-alumina material. Cerium was selected as the column filler material due to its high chemical stability. The elution of ⁹⁹ᵐTc was carried out using a NaCl solution, and quality control included assessments of radionuclidic purity, pH, and alumina content. The results showed that the generator with a cerium-alumina column composition increased the ⁹⁹ᵐTc yield by 6,62% compared to a conventional alumina column. However, the ⁹⁹Mo breakthrough still exceeded the limit set by the United States Pharmacopeia (>0,15 μCi ⁹⁹Mo/mCi ⁹⁹ᵐTc). By adding an additional alumina column, the ⁹⁹Mo breakthrough was reduced to 0,0015 μCi ⁹⁹Mo/mCi ⁹⁹ᵐTc, thereby meeting clinical quality standards for ⁹⁹ᵐTc. Overall, the findings demonstrate the potential of cerium-alumina-based non-fission generators for medical radioisotope production.
date: 2025-06-05
date_type: published
pages: 103
institution: UIN SUNAN KALIJAGA YOGYAKARTA
department: FAKULTAS SAINS DAN TEKNOLOGI
thesis_type: skripsi
thesis_name: other
citation:   Aidiana Mamluatun Ni’mah, NIM.: 21106020034  (2025) ANALISIS PROFIL ELUSI DAN KENDALI KUALITAS 99mTc HASIL PRODUKSI DARI GENERATOR 99Mo/99mTc NON-FISI BERBASIS CERIUM ALUMINA.  Skripsi thesis, UIN SUNAN KALIJAGA YOGYAKARTA.   
document_url: https://digilib.uin-suka.ac.id/id/eprint/71787/1/21106020034_BAB-I_IV-atau-V_DAFTAR-PUSTAKA.pdf
document_url: https://digilib.uin-suka.ac.id/id/eprint/71787/2/21106020034_BAB-II_sampai_SEBELUM-BAB-TERAKHIR.pdf