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ANALISIS MORFOLOGI DAN KARAKTERISTIK POTENSIAL MEMBRAN PADA MODEL SEL PURKINJE REALISTIK DAN REDUKSI TUGAS AKHIR
Purkinje cells are distinguished by their extensively branched dendritic trees, complex structural organization, and unique morphological and electrophysiological properties. They play a pivotal role in integrating motor signals within the cerebellum and serve as the sole output neurons of the cerebellar cortex. The complex morphology of Purkinje cell, with their extensive branching, requires substantial computational capacity for modeling. The use of reduce models can serve as an alternative for simulating such complex cells. This study simulates both realistic and reduced morphological models of Purkinje cells and compares their membrane potential characteristics using the NEURON simulator. The realistic model comprises a soma, 86 smooth dendrites, and 1,028 spiny dendrites. The reduced model consists of a soma, a main dendrite, a long smooth distal dendrite, a short smooth distal dendrite, a spiny distal dendrite, a spine neck, an adjacent dendrite, and three spines, along with six branches of smooth and spiny dendrites. The reduced model is constructed by considering four parameters: determining the surface area ratio, capacitance and resistance, the radius of each equivalent segment, and the length of each equivalent cylinder. The ion channel dynamics were modeled according to the Hodgkin–Huxley framework. Membrane potentials were recorded from the soma, main dendrite, smooth dendrite, spiny dendrite, and spine in both models. The simulation results demonstrated that both models produced identical simple spike and complex spike patterns. The reduced model successfully reproduced spikes equivalent to those of the realistic model while requiring fewer computational resources. These findings underscore the importance of selecting an appropriate modeling approach based on research objectives, balancing biological accuracy and computational efficiency.
FAKULTAS SAINS DAN TEKNOLOGI, UIN SUNAN KALIJAGA YOGYAKARTA
ANALISIS MORFOLOGI DAN KARAKTERISTIK POTENSIAL MEMBRAN PADA MODEL SEL PURKINJE REALISTIK DAN REDUKSI TUGAS AKHIR (Text)
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