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primary topic: http://digilib.uin-suka.ac.id/id/eprint/76371

http://digilib.uin-suka.ac.id/id/eprint/76371
type: Thesis
type: Article
title: IDENTIFIKASI SENYAWA CARVEOL DALAM EKSTRAK ETANOL DAUN SIRIH HIJAU (Pipper betle L.) MENGGUNAKAN GC-MS DAN KAJIAN POTENSINYA TERHADAP PROTEIN EGFR DAN PROTEIN PD-L1 SEBAGAI KANDIDAT ANTIKANKER PARU-PARU MELALUI PENDEKATAN BIOINFORMATIKA
abstract: Lung cancer ranks as the leading cause of cancer-related deaths worldwide. Lung cancer treatment includes surgery, radiation therapy, chemotherapy, immunotherapy, and targeted therapy, but these methods are often accompanied by significant side effects. Therefore, safer alternative treatments are needed. Betel leaves (Piper betle) are known to contain carveol compounds that have potential as anticancer agents. The identification of compounds in betel leaves was carried out using GC-MS methods, followed by molecular docking using SwissDock against lung cancer target proteins and pharmacokinetic (ADME) prediction using SwissADME. The docking results showed binding affinity values of -5.6 kcal/mol for the EFGR target protein and -7.5 kcal/mol for the PD-L1 protein. Cis-dihydrocarveol was able to interact with the EFGR protein at the Met793 residue through hydrogen bonds and hydrophobic interactions with the Val726, Ala743, Lys745, and Leu844 residues, as well as interact with the PD-L1 protein at the Pro133, Asn135, and Lys136 residues through hydrogen bonds and hydrophobic interactions at the Lys136 residue. ADME prediction shows a good pharmacokinetic profile. However, this compound can penetrate the BBB, so further testing is needed regarding its potential toxicity.
date: 2025-08-06
status: published
author list: authors
type: EPrint
type: ThesisEPrint
is part of: repository
has document: http://digilib.uin-suka.ac.id/id/document/1055239
has version: http://digilib.uin-suka.ac.id/id/document/1055239
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has document: http://digilib.uin-suka.ac.id/id/document/1055240
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has document: http://digilib.uin-suka.ac.id/id/document/1055247
has document: http://digilib.uin-suka.ac.id/id/document/1055248
subject: 660 Teknologi Kimia dan Ilmu yang Berkaitan

http://digilib.uin-suka.ac.id/id/document/1055239
type: Document
label: IDENTIFIKASI SENYAWA CARVEOL DALAM EKSTRAK ETANOL DAUN SIRIH HIJAU (Pipper betle L.) MENGGUNAKAN GC-MS DAN KAJIAN POTENSINYA TERHADAP PROTEIN EGFR DAN PROTEIN PD-L1 SEBAGAI KANDIDAT ANTIKANKER PARU-PARU MELALUI PENDEKATAN BIOINFORMATIKA (Text)
has file: 21106030033_BAB-I_IV-atau-V_DAFTAR-PUSTAKA.pdf
has part: 21106030033_BAB-I_IV-atau-V_DAFTAR-PUSTAKA.pdf

http://digilib.uin-suka.ac.id/id/document/1055240
type: Document
label: IDENTIFIKASI SENYAWA CARVEOL DALAM EKSTRAK ETANOL DAUN SIRIH HIJAU (Pipper betle L.) MENGGUNAKAN GC-MS DAN KAJIAN POTENSINYA TERHADAP PROTEIN EGFR DAN PROTEIN PD-L1 SEBAGAI KANDIDAT ANTIKANKER PARU-PARU MELALUI PENDEKATAN BIOINFORMATIKA (Text)

UIN SUNAN KALIJAGA YOGYAKARTA
type: Organization

FAKULTAS SAINS DAN TEKNOLOGI, UIN SUNAN KALIJAGA YOGYAKARTA
type: Organization

NIM.: 21106030033 Nabila Shafa Ariqah
type: Person
given name: NIM.: 21106030033
family name: Nabila Shafa Ariqah

http://digilib.uin-suka.ac.id/id/document/1055241
type: Document
label: IDENTIFIKASI SENYAWA CARVEOL DALAM EKSTRAK ETANOL DAUN SIRIH HIJAU (Pipper betle L.) MENGGUNAKAN GC-MS DAN KAJIAN POTENSINYA TERHADAP PROTEIN EGFR DAN PROTEIN PD-L1 SEBAGAI KANDIDAT ANTIKANKER PARU-PARU MELALUI PENDEKATAN BIOINFORMATIKA (Other)
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http://digilib.uin-suka.ac.id/id/document/1055242
type: Document
label: IDENTIFIKASI SENYAWA CARVEOL DALAM EKSTRAK ETANOL DAUN SIRIH HIJAU (Pipper betle L.) MENGGUNAKAN GC-MS DAN KAJIAN POTENSINYA TERHADAP PROTEIN EGFR DAN PROTEIN PD-L1 SEBAGAI KANDIDAT ANTIKANKER PARU-PARU MELALUI PENDEKATAN BIOINFORMATIKA (Other)
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http://digilib.uin-suka.ac.id/id/document/1055243
type: Document
label: IDENTIFIKASI SENYAWA CARVEOL DALAM EKSTRAK ETANOL DAUN SIRIH HIJAU (Pipper betle L.) MENGGUNAKAN GC-MS DAN KAJIAN POTENSINYA TERHADAP PROTEIN EGFR DAN PROTEIN PD-L1 SEBAGAI KANDIDAT ANTIKANKER PARU-PARU MELALUI PENDEKATAN BIOINFORMATIKA (Other)
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http://digilib.uin-suka.ac.id/id/document/1055244
type: Document
label: IDENTIFIKASI SENYAWA CARVEOL DALAM EKSTRAK ETANOL DAUN SIRIH HIJAU (Pipper betle L.) MENGGUNAKAN GC-MS DAN KAJIAN POTENSINYA TERHADAP PROTEIN EGFR DAN PROTEIN PD-L1 SEBAGAI KANDIDAT ANTIKANKER PARU-PARU MELALUI PENDEKATAN BIOINFORMATIKA (Other)
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http://digilib.uin-suka.ac.id/id/document/1055245
type: Document
label: IDENTIFIKASI SENYAWA CARVEOL DALAM EKSTRAK ETANOL DAUN SIRIH HIJAU (Pipper betle L.) MENGGUNAKAN GC-MS DAN KAJIAN POTENSINYA TERHADAP PROTEIN EGFR DAN PROTEIN PD-L1 SEBAGAI KANDIDAT ANTIKANKER PARU-PARU MELALUI PENDEKATAN BIOINFORMATIKA (Other)
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http://digilib.uin-suka.ac.id/id/document/1055246
type: Document
label: IDENTIFIKASI SENYAWA CARVEOL DALAM EKSTRAK ETANOL DAUN SIRIH HIJAU (Pipper betle L.) MENGGUNAKAN GC-MS DAN KAJIAN POTENSINYA TERHADAP PROTEIN EGFR DAN PROTEIN PD-L1 SEBAGAI KANDIDAT ANTIKANKER PARU-PARU MELALUI PENDEKATAN BIOINFORMATIKA (Other)
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http://digilib.uin-suka.ac.id/id/document/1055247
type: Document
label: IDENTIFIKASI SENYAWA CARVEOL DALAM EKSTRAK ETANOL DAUN SIRIH HIJAU (Pipper betle L.) MENGGUNAKAN GC-MS DAN KAJIAN POTENSINYA TERHADAP PROTEIN EGFR DAN PROTEIN PD-L1 SEBAGAI KANDIDAT ANTIKANKER PARU-PARU MELALUI PENDEKATAN BIOINFORMATIKA (Other)
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http://digilib.uin-suka.ac.id/id/document/1055248
type: Document
label: IDENTIFIKASI SENYAWA CARVEOL DALAM EKSTRAK ETANOL DAUN SIRIH HIJAU (Pipper betle L.) MENGGUNAKAN GC-MS DAN KAJIAN POTENSINYA TERHADAP PROTEIN EGFR DAN PROTEIN PD-L1 SEBAGAI KANDIDAT ANTIKANKER PARU-PARU MELALUI PENDEKATAN BIOINFORMATIKA (Other)
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https://digilib.uin-suka.ac.id/id/eprint/76371/
title: HTML Summary of #76371 IDENTIFIKASI SENYAWA CARVEOL DALAM EKSTRAK ETANOL DAUN SIRIH HIJAU (Pipper betle L.) MENGGUNAKAN GC-MS DAN KAJIAN POTENSINYA TERHADAP PROTEIN EGFR DAN PROTEIN PD-L1 SEBAGAI KANDIDAT ANTIKANKER PARU-PARU MELALUI PENDEKATAN BIOINFORMATIKA
format: text/html
primary topic: http://digilib.uin-suka.ac.id/id/eprint/76371

660 Teknologi Kimia dan Ilmu yang Berkaitan
type: Concept