ANALISIS GELOMBANG KALSIUM PADA NEURON PIRAMIDAL CA1: STUDI KOMPUTASI BERBASIS SIMULATOR NEURON

Churun Jauharoh Al-Aryachiyah, NIM. 17106020017 (2021) ANALISIS GELOMBANG KALSIUM PADA NEURON PIRAMIDAL CA1: STUDI KOMPUTASI BERBASIS SIMULATOR NEURON. Skripsi thesis, FAKULTAS SAINS DAN TEKNOLOGI.

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Abstract

Information on calcium dynamics in CA1 pyramidal neuron has not been widely revealed and needs to be followed up and evaluated with further in-vivo and in-vitro research. Computational study using the NEURON Simulator was carried out for modeling the realistic morphology of CA1 pyramidal neuron, studying the temporal dynamics of calcium waves, analyzing the spatial dynamics of calcium waves, analyzing the comparison of experimental calcium dynamics with modeling, and examining the effect of the initial intensity of InsP3 concentration on calcium dynamics. The modeling was constructed with adding Hodgkin Huxley conductance-based voltage gated ion channels and calcium-induced calcium-release (CICR) mechanism. The morphology of the neuron model consists of soma (cell body), basal dendritic branches and apical dendritic branches. The calcium wave represented by the concentration of calcium ions that propagates in these parts changes over time and there are differences in concentration amplitude among these parts. The amplitude of the calcium waves as a function of distance at the apical branch decreases with increasing distance from the soma in each branch which is in agreement with the experiment. The same modeling carried out to record basal commonly shows the reverse pattern to the apical had which was in contrast to the experiment. The basal recordings show identical spatial dynamics to apical together with modification of the distribution and conductance of ion channels. The maximum concentration of calcium is also influenced by the threshold value (initial concentration) of InsP3 with a proportional relation. Further and more spesific information about passive mechanisms and the distribution of calcium channels along basal are required for an evaluation and comprehensive analysis of the dynamics calcium waves with neuronal pathophysiology.

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