ANALISIS INTERAKSI SENYAWA MINYAK ATSIRI KAYU MANIS (Cinnamomum burmanii) DAN α-GLUKOSIDASE SECARA IN SILICO

Novita Sari Pranestri, NIM.: 18106040035 (2023) ANALISIS INTERAKSI SENYAWA MINYAK ATSIRI KAYU MANIS (Cinnamomum burmanii) DAN α-GLUKOSIDASE SECARA IN SILICO. Skripsi thesis, UIN SUNAN KALIJAGA YOGYAKARTA.

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Abstract

Type 2 diabetes melitus is a condition where patients experience a lack of insulin production which results in an increase in blood sugar levels beyond normal levels. One plant that is believed and used by the community as a cure for diabetes is the cinnamon plant (Cinnamomum burmannii). Bioactive compounds in cinnamon stem essential oil that have the ability to inhibit the work of α-glucosidase. The interaction of compounds that are α-glucosidase can be predicted by the in silico method. This study aims to screen and analyze compounds in cinnamon stem essential oil, namely Cinnamaldehyde, eugenol, coumarin, and cinnamyl acetate as ligands that have the potential to be inhibitors for α-glucosidase enzymes (receptors) in silico. The in silico method is used to predict the interaction and binding energy between bioactive compounds of cinnamon stem essential oil (ligands) with α-glucosidase proteins (receptors) that play a role in digestive metabolism. Essential oil compounds of cinnamon stems were analyzed by molecular docking. The docking results also show that the binding between the receptor and the ligand does not occur on the active side of the α-glucosidase, indicating that the ligand's inhibitory mechanism is as a competitive inhibitor. The results of the prediction of physicochemical properties of all compounds are categorized as good, the prediction of Lipinski's law for all compounds found no violations. ADME-Tox predictions for all four compounds are categorized as good so that they can qualify as good drug candidates. Based on these results, the couamrin compound in cinnamon stem essential oil can be proposed and further tested as a candidate for antidiabetic drugs.

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