PENENTUAN DISTRIBUSI DOSIS DALAM TERAPI KANKER KOLOREKTUM DENGAN BORON NEUTRON CAPTURE THERAPY (BNCT) BERBASIS PHITS 3.30

Tika Ayu Ariyanti, NIM.: 19106020019 (2023) PENENTUAN DISTRIBUSI DOSIS DALAM TERAPI KANKER KOLOREKTUM DENGAN BORON NEUTRON CAPTURE THERAPY (BNCT) BERBASIS PHITS 3.30. Skripsi thesis, UIN SUNAN KALIJAGA YOGYAKARTA.

Preview	Text (PENENTUAN DISTRIBUSI DOSIS DALAM TERAPI KANKER KOLOREKTUM DENGAN BORON NEUTRON CAPTURE THERAPY (BNCT) BERBASIS PHITS 3.30) 19106020019_BAB-I_IV-atau-V_DAFTAR-PUSTAKA.pdf - Published Version Download (3MB) | Preview
	Text (PENENTUAN DISTRIBUSI DOSIS DALAM TERAPI KANKER KOLOREKTUM DENGAN BORON NEUTRON CAPTURE THERAPY (BNCT) BERBASIS PHITS 3.30) 19106020019_BAB-II_sampai_SEBELUM-BAB-TERAKHIR.pdf - Published Version Restricted to Registered users only Download (4MB) | Request a copy

Abstract

The Boron Neutron Capture Therapy (BNCT) method is one of the solutions to the high mortality rate caused by cancer, especially for colorectal cancer. BNCT is highly effective in cancer therapy as it can selectively destroy cancer cells. The purposes of this research include analyzing the influence of Boron concentration on the total dose rate and irradiation time, as well as determining the doses received by organs at risk surrounding the cancer. This research was conducted using the Monte Carlo method through the simulating the irradiation of colorectal cancer using the Particle and Heavy Ion Transport Code System (PHITS) version 3.30. The Boron concentrations used in this research were 50, 75, 100, 125, and 150 μg/g of cancer tissue. Neutron irradiation was performed from three directions: from the left side (Left-Lateral - LLAT), the back of the body (Posterior-Anterior - PA), and front of the body (Anterior-Posterior (AP). The results of the simulation show that an increase in Boron concentration leads to a higher total dose rate and shorter irradiation time. The optimal Boron concentration is 150 μg/g of cancer tissue, as it provides the highest dose rate and shortest irradiation time. With that Boron concentration, the most effective irradiation direction in this research is through front (AP) direction, with a total dose rate of 1.90E-2 Gy/s and the shortest irradiation time of 43 minutes. Furthermore, the doses received by organs at risk are still within safe limits. The organs at risk that are in close to the cancer are the large intestine, small intestine, and stomach, each receiving doses 24,45 Gy.Eq, 2,11 Gy.Eq and 0,79 Gy.Eq.

Share this knowledge with your friends :

Actions (login required)

View Item